1 Department of Medicine, Division Gastroenterology, 2 Research, Central Texas Veterans Health Care System, 3 Scott & White Digestive Disease Research Center, Scott & White, and Texas A&M Health Science Center, College of Medicine, Temple, TX 76504, USA ; 4 Experimental Medicine, University of L'Aquila, L'Aquila, Italy ; 5 Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University Sapienza, Rome, Italy.
Ann Transl Med. 2013 Oct;1(3):29. doi: 10.3978/j.issn.2305-5839.2012.12.01.
Secretin is secreted by S cells in the small intestine and affects the function of a number of organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several cell types. In addition to regulating the secretion of a number of epithelia (e.g., in the pancreas and biliary epithelium in the liver), secretin exerts trophic effects in several cell types. In this article, we will provide a comprehensive review on the multiple roles of secretin and SR signaling in the regulation of epithelial functions in various organ systems with particular emphasis in the liver. We will discuss the role of secretin and its receptor in health and biliary disease pathogenesis. Finally, we propose future areas of research for the further evaluation of the secretin/secretin receptor axis in liver pathophysiology.
缩胆囊素由小肠的 S 细胞分泌，并影响许多器官系统的功能。缩胆囊素受体 (SR) 在几种细胞类型的基底外侧域表达。除了调节许多上皮细胞的分泌（例如，在胰腺和肝脏中的胆管上皮中）外，缩胆囊素还对几种细胞类型发挥营养作用。在本文中，我们将全面回顾缩胆囊素和 SR 信号在各种器官系统中调节上皮功能的多种作用，特别强调肝脏。我们将讨论缩胆囊素及其受体在健康和胆道疾病发病机制中的作用。最后，我们提出了未来的研究领域，以进一步评估缩胆囊素/缩胆囊素受体轴在肝病理生理学中的作用。
