PMX - 622（多粘菌素B - 葡聚糖70）不会改变11种抗菌药物的体外活性。
PMX-622 (polymyxin B-dextran 70) does not alter in vitro activities of 11 antimicrobial agents.
作者信息
Fuchs P C, Barry A L, Brown S D
机构信息
The Clinical Microbiology Institute, Wilsonville, Oregon 97070, USA.
出版信息
Antimicrob Agents Chemother. 1998 Oct;42(10):2765-7. doi: 10.1128/AAC.42.10.2765.
Abstract
Because of its capacity to neutralize the lethality of gram-negative bacterial endotoxic lipopolysaccharides, PMX-622 (polymyxin B bound to dextran 70) is being developed for possible adjunctive therapy of gram-negative sepsis. In this study, it was determined that the in vitro antimicrobial activity of PMX-622 was minimal and that it does not interfere with the in vitro antimicrobial activity of 11 antibiotics commonly used to treat gram-negative infections.
摘要
由于PMX - 622（多粘菌素B与葡聚糖70结合物）具有中和革兰氏阴性菌内毒素脂多糖致死性的能力，目前正在开发其用于革兰氏阴性菌败血症的可能辅助治疗。在本研究中，已确定PMX - 622的体外抗菌活性极小，且它不干扰常用于治疗革兰氏阴性菌感染的11种抗生素的体外抗菌活性。
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