Shirai H, Sato T, Hara T, Minagi S
Department of Removable Prosthodontics, Okayama University Dental School, Okayama City, Japan.
J Oral Rehabil. 1998 Sep;25(9):715-20. doi: 10.1046/j.1365-2842.1998.00301.x.
Histopathological changes in the tissues under a denture base were studied with respect to the difference between diabetic and normal rats. Diabetes mellitus was induced in Wistar rats by streptozotocin. The experimental denture base was designed to make contact with the palatal mucosa without any continuous nor masticatory pressure. Histopathological observation periods were 1, 2, 4, 8, 12 and 20 weeks after the insertion of the denture base. Histopathological examination revealed that only the transient slight proliferative reaction observed in mucosal epithelium under a denture base in normal non-diabetic rats, was lessened by induced diabetes mellitus. Moreover, covering the palatal mucosa with a denture base without any continuous nor masticatory pressure and with the maintenance of mucosal cleanliness under it and of the denture itself, did not cause any inflammatory change or bone resorption in the tissues under the base.
针对糖尿病大鼠和正常大鼠的差异，研究了义齿基托下组织的组织病理学变化。通过链脲佐菌素诱导Wistar大鼠患糖尿病。实验性义齿基托设计为与腭黏膜接触，无任何持续或咀嚼压力。义齿基托插入后1、2、4、8、12和20周为组织病理学观察期。组织病理学检查显示，在正常非糖尿病大鼠义齿基托下的黏膜上皮中观察到的短暂轻微增殖反应，在诱导糖尿病后减轻。此外，用无任何持续或咀嚼压力的义齿基托覆盖腭黏膜，并保持其下方黏膜和义齿本身的清洁，不会导致基托下组织出现任何炎症变化或骨吸收。
