Hara T, Sato T, Nakashima K, Minagi S
Department of Removable Prosthodontics, Okayama University Dental School, Japan.
J Oral Rehabil. 1996 Jun;23(6):363-71. doi: 10.1111/j.1365-2842.1996.tb00865.x.
Histopathological changes in the denture supporting tissues in relation to the occlusal pressure exerted through an experimental denture base were studied. An experimental denture, which prescribed the occlusal pressure by the amount of subsidence of the denture base (100, 50 and 13 microns), was constructed for the palate of the molar region of rat. Histopathological changes caused by the occlusal pressure were observed, and the intensity of the pressure was also estimated. In the 100 microns subsidence group, compression of epithelium and lamina propria mucosae, inflammatory change and bone resorption were caused by the occlusal pressure. In the 50 microns subsidence group, compression of epithelium and lamina propria mucosae and bone resorption were observed, while in the 13 microns subsidence group, no evidence of inflammatory change and bone resorption were observed. The epithelium and lamina propria mucosae recovered histopathologically depending on the gradual decrease of the occlusal pressure resulting from bone resorption, whereas no quantitative recovery of the resorbed bone tissue was observed in the 100 and 50 microns subsidence groups. From the results observed in this study, a high correlation was observed between the histopathological changes under a denture base and the intensity of the occlusal pressure, and the possibility of the existence of the threshold for bone resorption induced by occlusal pressure was suggested.
研究了通过实验性义齿基托施加的咬合压力与义齿支持组织的组织病理学变化之间的关系。为大鼠磨牙区的腭部制作了一种实验性义齿，该义齿通过义齿基托的下沉量（100、50和13微米）来规定咬合压力。观察了由咬合压力引起的组织病理学变化，并评估了压力强度。在下沉100微米的组中，咬合压力导致上皮和固有层黏膜受压、炎症改变和骨吸收。在下沉50微米的组中，观察到上皮和固有层黏膜受压以及骨吸收，而在下沉13微米的组中，未观察到炎症改变和骨吸收的迹象。随着骨吸收导致咬合压力逐渐降低，上皮和固有层黏膜在组织病理学上得以恢复，而在下沉100和50微米的组中，未观察到吸收的骨组织有定量恢复。从本研究观察到的结果来看，义齿基托下的组织病理学变化与咬合压力强度之间存在高度相关性，并提示存在由咬合压力引起骨吸收的阈值的可能性。
