Mori S, Sato T, Hara T, Nakashima K, Minagi S
Department of Removable Prosthodontics, Okayama University Dental School, Japan.
J Oral Rehabil. 1997 Jan;24(1):37-46. doi: 10.1046/j.1365-2842.1997.00443.x.
The histopathological changes in denture-supporting tissues were studied in relation to continuous pressure exerted through an experimental denture base. The experimental dentures were designed to load continuous pressures (1.5, 3.4 or 4.9 kPa) to the palate of molar region of rat. Histopathological changes caused by the continuous pressure were observed, and the intensity of the pressure was also estimated. A high correlation was observed between the histopathological changes under the denture base and the intensity of the continuous pressure. In groups exposed to 4.9 and 3.4 kPa, the continuous mechanical pressure caused bone resorption; in 1.5 kPa group, no evidence of bone resorption was observed. The epithelium and lamina propria mucosa under the denture base, which were compressed by the continuous pressure, recovered histopathologically depending on the decrease of the pressure caused by bone resorption; no quantitative recovery of the absorbed bone tissue was observed. No inflammatory change was induced by the continuous pressure. From the histopathological results observed in this study, the possibility of the existence of a threshold for bone resorption induced by continuous pressure was suggested.
通过实验性义齿基托施加持续压力，研究义齿支持组织的组织病理学变化。实验性义齿设计用于对大鼠磨牙区腭部施加持续压力（1.5、3.4或4.9 kPa）。观察持续压力引起的组织病理学变化，并评估压力强度。观察到义齿基托下的组织病理学变化与持续压力强度之间存在高度相关性。在暴露于4.9 kPa和3.4 kPa的组中，持续的机械压力导致骨吸收；在1.5 kPa组中，未观察到骨吸收的证据。义齿基托下被持续压力压缩的上皮和黏膜固有层，根据骨吸收导致的压力降低在组织病理学上得以恢复；未观察到吸收的骨组织有定量恢复。持续压力未诱发炎症变化。根据本研究观察到的组织病理学结果，提示存在持续压力诱导骨吸收阈值的可能性。
