School of Health Sciences and Sports, Macao Polytechnic Institute, Macao, China.
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu610041, China.
Epidemiol Infect. 2021 Apr 26;149:e120. doi: 10.1017/S0950268821000923.
Recently, the antibacterial properties of oestrogen and progestogen were discovered. The aim of this study was to find the cross-sectional association between oral contraceptive use and Helicobacter pylori seroprevalence. Data were obtained from the US National Health and Nutrition Examination Survey (NHANES). The H. pylori immunoglobulin G (IgG) enzyme-linked immunosorbent assays were used to categorise participants as seropositive or seronegative. The study population included 799 female participants who had information on H. pylori seroprevalence and all other covariates and had not been taking any medications (except oral contraceptives). The bivariate Rao-Scott chi-square test indicated a significant association between H. pylori seroprevalence and contraceptive use (P < 0.01). The variables of race, education, poverty income ratio, smoking, and blood lead and cadmium levels were also significantly associated with H. pylori seroprevalence (P < 0.01). Multiple logistic regression analysis of the age-adjusted model revealed that contraceptive users are 65% less likely of being H. pylori seropositive as compared to non-contraceptive users (odds ratio (OR): 0.35, 95% confidence interval (CI): 0.18-0.68). This association is stronger with the final multivariate model (OR: 0.46, 95% CI: 0.23-0.89). Conclusions: This finding reveals the potential protective effect of oral contraceptives against H. pylori infection and serves as a foundation study for further investigations.
最近，人们发现雌激素和孕激素具有抗菌特性。本研究旨在探讨口服避孕药的使用与幽门螺杆菌血清阳性率之间的横断面相关性。数据来自美国国家健康和营养调查（NHANES）。采用幽门螺杆菌免疫球蛋白 G（IgG）酶联免疫吸附试验将参与者分为血清阳性或血清阴性。本研究人群包括 799 名女性参与者，她们具有幽门螺杆菌血清阳性率和所有其他协变量的信息，且未服用任何药物（除口服避孕药外）。双变量 Rao-Scott 卡方检验表明，幽门螺杆菌血清阳性率与避孕药使用之间存在显著关联（P<0.01）。种族、教育、贫困收入比、吸烟以及血铅和镉水平等变量也与幽门螺杆菌血清阳性率显著相关（P<0.01）。对年龄调整模型进行多因素逻辑回归分析显示，与非避孕药使用者相比，避孕药使用者幽门螺杆菌血清阳性的可能性降低 65%（比值比（OR）：0.35，95%置信区间（CI）：0.18-0.68）。这种关联在最终的多变量模型中更为强烈（OR：0.46，95%CI：0.23-0.89）。结论：这一发现揭示了口服避孕药对幽门螺杆菌感染的潜在保护作用，为进一步研究奠定了基础。
