Grin C M, Driscoll M S, Grant-Kels J M
Department of Dermatology, The University of Connecticut Health Center, Farmington 06030, USA.
Semin Cutan Med Surg. 1998 Sep;17(3):167-71. doi: 10.1016/s1085-5629(98)80010-2.
There has been considerable interest in the relationship of pregnancy and melanoma. Since 1951, a number of case reports have suggested that pregnancy may induce or exacerbate melanoma. Likewise, there has been concern over the relationship between exposure to oral contraceptives (OCs) or hormone replacement therapy (HRT) and possible increased risk of melanoma. We critically reviewed: (1) controlled clinical trials to assess the effect of pregnancy on the prognosis of melanoma; and (2) epidemiological data to evaluate the risk of melanoma after exposure to OCs or HRT. Pregnancy before, during, or after the diagnosis of melanoma does not appear to influence 5-year survival rates. Exposure to OCs or HRT does not appear to increase the risk of melanoma.
人们对妊娠与黑色素瘤之间的关系一直相当关注。自1951年以来，多项病例报告表明妊娠可能诱发或加重黑色素瘤。同样，人们也担心口服避孕药（OCs）或激素替代疗法（HRT）的暴露与黑色素瘤风险可能增加之间的关系。我们进行了严格审查：（1）评估妊娠对黑色素瘤预后影响的对照临床试验；（2）评估OCs或HRT暴露后黑色素瘤风险的流行病学数据。黑色素瘤诊断之前、期间或之后的妊娠似乎不会影响5年生存率。暴露于OCs或HRT似乎不会增加黑色素瘤风险。
