Franceschi S, Barón A E, La Vecchia C
Epidemiology Unit, Aviano Cancer Center, Pordenone, Italy.
Tumori. 1990 Oct 31;76(5):439-49. doi: 10.1177/030089169007600505.
Several lines of biological evidence have suggested a relationship between the behaviour of melanocytes and cutaneous malignant melanoma (CMM) and the action of female hormones. The present overview, however, indicates that the effect of reproductive, menstrual and hormonal factors, including oral contraceptives, on onset and outcome of CMM must be very weak, if any. The only consistent findings which may suggest a role of female hormones on CMM seem to be: 1) a different distribution by anatomic site in men and women, and 2) a more favorable outcome of CMM in women as compared to men. Neither of them, however, necessarily implies a direct effect of female hormones on CMM.
多条生物学证据表明黑素细胞行为与皮肤恶性黑色素瘤（CMM）以及女性激素的作用之间存在关联。然而，本综述表明，生殖、月经和激素因素（包括口服避孕药）对CMM发病和预后的影响（如果有影响的话）必定非常微弱。唯一可能提示女性激素在CMM中起作用的一致发现似乎是：1）男性和女性CMM在解剖部位的分布不同，以及2）与男性相比，女性CMM的预后更有利。然而，这两者都不一定意味着女性激素对CMM有直接影响。
