Niijima A, Chun S J, Shima T, Bizot-Espiard J G, Guardiola-Lemaitre B, Nagai K
Department of Physiology, Niigata University School of Medicine, Japan.
J Auton Nerv Syst. 1998 Jul 15;71(2-3):134-8. doi: 10.1016/s0165-1838(98)00067-8.
The effect of intravenous administration of melatonin on the efferent activity of the adrenal nerve was investigated in the rat. Intravenous infusion of 1 or 2 ng melatonin resulted in a decrease, and 10 or 20 ng or larger amount of melatonin caused an increase in the efferent activity of the adrenal nerve. The least effective dose for the suppressive activity of melatonin was 100 pg and the response is dose-related. Administration of either 1 ng or 10 ng of melatonin did not change the plasma glucose concentration until 30 min after the administration. Hepatic vagotomy eliminates the inhibitory effect of melatonin. These results suggest that melatonin sensors in the hepato-portal region and melatonin receptors in the SCN play important roles in the regulation of sympathetic outflow to the adrenal medulla.
在大鼠中研究了静脉注射褪黑素对肾上腺神经传出活动的影响。静脉输注1或2纳克褪黑素会导致肾上腺神经传出活动减少，而10或20纳克及更大剂量的褪黑素会导致肾上腺神经传出活动增加。褪黑素抑制活性的最小有效剂量为100皮克，且反应与剂量相关。注射1纳克或10纳克褪黑素在给药后30分钟内均未改变血浆葡萄糖浓度。肝迷走神经切断术消除了褪黑素的抑制作用。这些结果表明，肝门区域的褪黑素传感器和视交叉上核中的褪黑素受体在调节肾上腺髓质的交感神经输出中起重要作用。
