Lacroix-Desmazes S, Kaveri S V, Mouthon L, Ayouba A, Malanchère E, Coutinho A, Kazatchkine M D
INSERM U430, Hôpital Broussais and Université Pierre et Marie Curie, and CNRS URA 1961, Institut Pasteur, Paris, France.
J Immunol Methods. 1998 Jul 1;216(1-2):117-37. doi: 10.1016/s0022-1759(98)00074-x.
Antibodies that are present in the serum of healthy individuals in the absence of deliberate immunization with any antigen, are refered to as natural antibodies. A vast majority of natural antibodies react with one or more self antigens and are termed as natural autoantibodies. The importance of natural autoantibodies in immune regulation has long been neglected, since tolerance to self was thought to be primarily dependent on the deletion of autoreactive clones, rather than on peripheral suppressive mechanisms. Clonal deletion and energy cannot account, however, for the prevalence of natural autoreactivity among healthy individuals. It is now well established that autoreactive antibodies and B cells, and autoreactive T cells, are present in healthy individuals, and in virtually all vertebrate species. Autoreactive repertoires are predominantly selected early in ontogeny. Questions pertaining to the role of natural antibodies in the regulation of the immune response and maintenance of immune homeostasis and to the distinction between natural autoreactivity and pathological autoimmunity have not been adequately addressed. Here, we focus on the current knowledge on the physicochemical and functional properties of NAA in man, and the use of NAA for therapeutic intervention. reserved.
在未对任何抗原进行刻意免疫的情况下，健康个体血清中存在的抗体被称为天然抗体。绝大多数天然抗体与一种或多种自身抗原发生反应，被称为天然自身抗体。长期以来，天然自身抗体在免疫调节中的重要性一直被忽视，因为人们认为对自身的耐受性主要依赖于自身反应性克隆的缺失，而非外周抑制机制。然而，克隆缺失和失能并不能解释健康个体中天然自身反应性的普遍存在。现在已经明确，自身反应性抗体、B细胞和自身反应性T细胞存在于健康个体以及几乎所有脊椎动物物种中。自身反应性库主要在个体发育早期被选择。关于天然抗体在免疫反应调节和免疫稳态维持中的作用，以及天然自身反应性与病理性自身免疫之间的区别等问题，尚未得到充分解决。在这里，我们聚焦于目前关于人类天然自身抗体的物理化学和功能特性的知识，以及天然自身抗体在治疗干预中的应用。保留。
