Institut des Cordeliers, INSERM U681, 15 Rue de l'Ecole de Médecine, 75006 Paris, France.
Expert Rev Clin Immunol. 2005 Jul;1(2):213-22. doi: 10.1586/1744666X.1.2.213.
The importance of natural autoantibodies reacting with self-antigens has long been neglected, as tolerance to self was believed to be primarily dependent on the deletion of autoreactive clones during ontogeny. However, it is now well established that autoreactive antibodies and B- and T-cells are present in healthy individuals. Research into the properties of natural autoantibodies and their role in immune homeostasis has been extensively investigated for a number of years. This information should lead towards the therapeutic exploitation of natural autoantibodies in the immunotherapy of autoimmune and inflammatory disorders.
长期以来，与自身抗原反应的天然自身抗体的重要性一直被忽视，因为人们认为对自身的耐受性主要依赖于个体发生过程中自身反应性克隆的删除。然而，现在已经证实，健康个体中存在自身反应性抗体和 B 细胞和 T 细胞。多年来，人们广泛研究了天然自身抗体的特性及其在免疫稳态中的作用。这些信息应该有助于在自身免疫和炎症性疾病的免疫治疗中利用天然自身抗体。
