Corradetti R, Pugliese A M
Department of Preclinical and Clinical Pharmacology Mario Aiazzi-Mancini, Università di Firenze, Italy.
Life Sci. 1998;63(13):1075-88. doi: 10.1016/s0024-3205(98)00230-6.
Felbamate is a broad spectrum antiepileptic drug recently introduced into clinical practice for controlling seizures in patients affected by Lennox-Gastaut epilepsy, complex partial seizures or otherwise intractable epilepsies. However, the cellular mechanisms by which the drug exerts its anticonvulsant actions are not fully understood. The aim of the present article is to outline the possible mechanisms of action of felbamate as suggested by findings obtained with electrophysiological approaches.
非氨酯是一种广谱抗癫痫药物，最近被引入临床实践，用于控制患有伦诺克斯-加斯托综合征、复杂部分性发作或其他难治性癫痫的患者的癫痫发作。然而，该药物发挥抗惊厥作用的细胞机制尚未完全明确。本文旨在概述电生理学方法所得结果所提示的非氨酯可能的作用机制。
