Bermejo Benito P, Abad Martínez M J, Silván Sen A M, Sanz Gómez A, Fernández Matellano L, Sánchez Contreras S, Díaz Lanza A M
Department of Pharmacology, Faculty of Pharmacy, University Complutense, Madrid, Spain.
Life Sci. 1998;63(13):1147-56. doi: 10.1016/s0024-3205(98)00376-2.
Buddlejasaponin I and saikosaponin 1 and 2, biologically active compounds from Scrophularia scorodonia and Bupleurum rigidum respectively, exert potent in vivo antiinflammatory effects on mouse ear edema induced by phorbol myristate acetate (PMA). The effects of these compounds on swelling and other inflammatory parameters are described. In screening for in vitro effects of saikosaponins on cellular systems generating cyclooxygenase (COX) and lipoxygenase (LOX) metabolites, we observed that most saikosaponins showed a significant effect. The action is more marked on LOX metabolite LTC4. Our data support the inhibition of arachidonic acid metabolism as one of the biochemical mechanisms that might be the rationale for the putative antiphlogistic activity of these saikosaponins.
醉鱼草皂苷I以及柴胡皂苷1和2分别是玄参和硬柴胡中的生物活性化合物，它们对佛波酯（PMA）诱导的小鼠耳肿胀具有显著的体内抗炎作用。本文描述了这些化合物对肿胀及其他炎症参数的影响。在筛选柴胡皂苷对产生环氧化酶（COX）和脂氧合酶（LOX）代谢物的细胞系统的体外作用时，我们观察到大多数柴胡皂苷都有显著作用。这种作用对LOX代谢物白三烯C4更为明显。我们的数据支持花生四烯酸代谢的抑制是这些柴胡皂苷可能具有抗炎活性的生化机制之一。
