抽动秽语综合征中与运动任务相关的大脑异常激活。
Abnormal cerebral activation associated with a motor task in Tourette syndrome.
作者信息
Biswal B, Ulmer J L, Krippendorf R L, Harsch H H, Daniels D L, Hyde J S, Haughton V M
机构信息
Department of Biophysics, Medical College of Wisconsin, Milwaukee 53226, USA.
出版信息
AJNR Am J Neuroradiol. 1998 Sep;19(8):1509-12.
BACKGROUND AND PURPOSE
In Gilles de la Tourette syndrome, PET scanning and EEG suggest an abnormal organization of the sensorimotor cortex and basal ganglia. The purpose of this study was to use functional MR imaging to study activation in the sensorimotor cortex in patients with Tourette syndrome.
METHODS
From echo-planar images acquired during intermittent performance of a finger-tapping task, the location of activated pixels was determined by means of conventional signal processing methods. In five patients with Tourette syndrome and five healthy volunteers, the number of activated pixels in the sensorimotor cortices and supplementary motor areas were counted. The area over which the activation was distributed was calculated.
RESULTS
In the five patients, the average number of pixels activated during the finger-tapping task in the sensorimoter cortices and supplementary motor area (69.4 pixels) exceeded that in the volunteers (49.2 pixels). The difference was significant. The area over which the pixels was distributed was significantly larger (25.4 vs 13.8 cm2).
CONCLUSION
Motor function is organized differently in patients with Tourette syndrome than in healthy subjects.
背景与目的
在抽动秽语综合征中，正电子发射断层扫描（PET）和脑电图（EEG）提示感觉运动皮层和基底神经节存在组织异常。本研究的目的是使用功能磁共振成像（fMRI）研究抽动秽语综合征患者感觉运动皮层的激活情况。
方法
从在间歇性手指敲击任务期间采集的回波平面图像中，通过传统信号处理方法确定激活像素的位置。在5名抽动秽语综合征患者和5名健康志愿者中，对感觉运动皮层和辅助运动区中激活像素的数量进行计数。计算激活分布的区域。
结果
在这5名患者中，手指敲击任务期间感觉运动皮层和辅助运动区激活的平均像素数（69.4个像素）超过了志愿者（49.2个像素）。差异具有统计学意义。像素分布的区域明显更大（25.4平方厘米对13.8平方厘米）。
结论
抽动秽语综合征患者的运动功能组织与健康受试者不同。
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