Suominen P, Punnonen K, Rajamäki A, Irjala K
Central Laboratory, Department of Clinical Chemistry and Department of Hematology, Turku University Central Hospital, Turku, Finland.
Blood. 1998 Oct 15;92(8):2934-9.
Despite the established utility of serum transferrin receptor (sTfR), serum ferritin, and the sTfR/log ferritin ratio (TfR-F Index) in the diagnosis of iron deficiency (ID) anemia, the numeric values of these parameters, which are indicative of subclinical ID, remain to be clearly defined. In this study, 65 apparently healthy nonanemic adults (22 men and 43 women) were treated with 3 months of oral iron supplementation to evaluate its effect on parameters reflecting iron status and to determine the prevalence of subclinical iron deficiency in apparently healthy adults. Significant supplementation-induced changes were observed in sTfR, ferritin, and TfR-F Index values in women, whereas in men, none of the studied parameters showed any significant change. Iron-deficient erythropoiesis (IDE) was not observed in men, but was found in 17 women (40%). Although individuals with a compromised iron status may be represented in substantial numbers in conventional reference populations, they can be readily identified using sTfR, ferritin, and TfR-F Index determinations.
尽管血清转铁蛋白受体（sTfR）、血清铁蛋白以及sTfR/铁蛋白对数比值（TfR-F指数）在缺铁（ID）性贫血的诊断中具有既定效用，但这些指示亚临床ID的参数的数值仍有待明确界定。在本研究中，65名表面健康的非贫血成年人（22名男性和43名女性）接受了为期3个月的口服铁补充剂治疗，以评估其对反映铁状态参数的影响，并确定表面健康成年人中亚临床铁缺乏的患病率。在女性中观察到sTfR、铁蛋白和TfR-F指数值因补充剂而发生显著变化，而在男性中，所研究的参数均未显示出任何显著变化。男性未观察到缺铁性红细胞生成（IDE），但在17名女性（40%）中发现了IDE。尽管在传统参考人群中可能有大量铁状态受损的个体，但使用sTfR、铁蛋白和TfR-F指数测定可以很容易地识别出他们。
