Aguilar-Rebolledo F, Zárate-Moysén A, Quintana-Roldán G
Servicio de Neurología, Centro Médico Nacional Siglo XXI, IMSS, México, D.F.
Rev Invest Clin. 1998 May-Jun;50(3):217-20.
To describe the clinical and ethiologic findings of children with Parinaud's syndrome.
11 children fulfilling the clinical criteria for Parinaud's syndrome were studied. The mean age was 10 years with a range of 10 months to 14 years.
Seven cases were tumors (pineal germinoma in four and one each with teratoma, astrocytoma, and an undefined tumor); the remaining 4 cases corresponded to arachnoid cyst in the III ventricule, cysticercosis, tuberculoma and multiple sclerosis. The main treatment was surgical including ventriculoperitoneal shunt because of hydrocephalous secondary to mechanical obstruction. Chemotherapy and radiotherapy were also used for the tumor cases, and steroids for the multiple sclerosis patient.
In contrast to adults, Parinaud's syndrome in our children was associated with a mass, mainly tumoral, which interrupted the afferent and efferent connections of the midbrain structures, such as posterior commissure, riMLF or the interstitial nucleus of Cajal.
描述患有帕里诺综合征儿童的临床及病因学表现。
对11名符合帕里诺综合征临床标准的儿童进行了研究。平均年龄为10岁，范围在10个月至14岁之间。
7例为肿瘤（4例松果体生殖细胞瘤，畸胎瘤、星形细胞瘤和未明确肿瘤各1例）；其余4例分别为第三脑室蛛网膜囊肿、囊尾蚴病、结核瘤和多发性硬化症。主要治疗方法为手术，因机械性梗阻继发脑积水而行脑室腹腔分流术。肿瘤病例还采用了化疗和放疗，多发性硬化症患者使用了类固醇。
与成人不同，我们研究中的儿童帕里诺综合征与肿块有关，主要是肿瘤，它中断了中脑结构如后连合、中脑被盖背侧纵束或 Cajal 间质核的传入和传出连接。
