幽门螺杆菌感染中的细菌因素与免疫发病机制

Bacterial factors and immune pathogenesis in Helicobacter pylori infection.

作者信息

Shimoyama T, Crabtree J E

机构信息

First Department of Internal Medicine, Hirosaki University School of Medicine, Japan.

出版信息

Gut. 1998 Jul;43 Suppl 1(Suppl 1):S2-5.

DOI:

PMID:9764030

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1766604/

Abstract

Virulent Helicobacter pylori strains which have been clinically associated with severe outcome induce increased gastric mucosal immune responses. Although several bacterial pathogenic factors have been shown to have a considerable role in H pylori infection, variability in host immune responses may also contribute to mucosal damage in H pylori associated gastritis.

摘要

临床上与严重后果相关的毒力幽门螺杆菌菌株会诱导胃黏膜免疫反应增强。尽管已表明几种细菌致病因素在幽门螺杆菌感染中起重要作用，但宿主免疫反应的变异性也可能导致幽门螺杆菌相关性胃炎的黏膜损伤。