Liu Ning-Ning, Ma Qiang, Ge Yang, Yi Cheng-Xiang, Wei Lu-Qi, Tan Jing-Cong, Chu Qiao, Li Jing-Quan, Zhang Peng, Wang Hui
State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.
Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University, Shanghai, China.
NPJ Precis Oncol. 2020 Dec 10;4(1):33. doi: 10.1038/s41698-020-00138-z.
The correlations between microbiota dysbiosis and cancer have gained extensive attention and been widely explored. As a leading cancer diagnosis worldwide, lung cancer poses a great threat to human health. The healthy human lungs are consistently exposed to external environment and harbor a specific pattern of microbiota, sharing many key pathological and physiological characteristics with the intestinal tract. Although previous findings uncovered the critical roles of microbiota in tumorigenesis and response to anticancer therapy, most of them were focused on the intestinal microbiota rather than lung microbiota. Notably, the considerable functions of microbiota in maintaining lung homeostasis should not be neglected as the microbiome dysbiosis may promote tumor development and progression through production of cytokines and toxins and multiple other pathways. Despite the fact that increasing studies have revealed the effect of microbiome on the induction of lung cancer and different disease status, the underlying mechanisms and potential therapeutic strategies remained unclear. Herein, we summarized the recent progresses about microbiome in lung cancer and further discussed the role of microbial communities in promoting lung cancer progression and the current status of therapeutic approaches targeting microbiome to alleviate and even cure lung cancer.
微生物群失调与癌症之间的相关性已引起广泛关注并得到广泛探索。作为全球主要的癌症诊断类型，肺癌对人类健康构成巨大威胁。健康人的肺部持续暴露于外部环境中，并拥有特定模式的微生物群，与肠道具有许多关键的病理和生理特征。尽管先前的研究发现了微生物群在肿瘤发生和抗癌治疗反应中的关键作用，但其中大多数都集中在肠道微生物群而非肺部微生物群。值得注意的是，微生物群在维持肺稳态中的重要功能不应被忽视，因为微生物群失调可能通过产生细胞因子和毒素以及多种其他途径促进肿瘤发展和进展。尽管越来越多的研究揭示了微生物群对肺癌诱导和不同疾病状态的影响，但其潜在机制和潜在治疗策略仍不清楚。在此，我们总结了关于微生物群在肺癌方面的最新进展，并进一步讨论了微生物群落促进肺癌进展的作用以及针对微生物群的治疗方法以减轻甚至治愈肺癌的现状。
