抑酸与胃萎缩：分清事实与虚构
Acid suppression and gastric atrophy: sifting fact from fiction.
作者信息
Genta R M
机构信息
Department of Pathology, Medicine, Veterans Affairs Medical Center, Houston, TX, USA.
出版信息
Gut. 1998 Jul;43 Suppl 1(Suppl 1):S35-8. doi: 10.1136/gut.43.2008.s35.
Abstract
Prolonged pharmacological acid suppression is associated with various histological changes in the gastric mucosa, particularly in Helicobacter pylori infected patients. In a number of subjects these changes include a shift in the gastric inflammation from the antrum to the corpus. This finding has been interpreted as gastric atrophy, and the possibility that acid suppression accelerates the progress of lesions that may lead to gastric cancer has been considered. Two recent studies on the relation between treatment with proton pump inhibitors and atrophic gastritis have yielded apparently contradictory results. These studies are reviewed in detail here and some of the possible reasons for the discrepant conclusions are explored. In particular, the way the terms "gastric atrophy" and "atrophic gastritis" are used is examined critically.
摘要
长期药物性抑酸与胃黏膜的各种组织学改变有关，尤其是在幽门螺杆菌感染患者中。在许多受试者中，这些改变包括胃炎症从胃窦向胃体的转移。这一发现被解释为胃萎缩，并且人们已经考虑到抑酸可能加速可能导致胃癌的病变进展。最近两项关于质子泵抑制剂治疗与萎缩性胃炎关系的研究得出了明显矛盾的结果。本文详细回顾了这些研究，并探讨了得出不同结论的一些可能原因。特别是，对“胃萎缩”和“萎缩性胃炎”这两个术语的使用方式进行了批判性审视。
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本文引用的文献
1
Parietal cell protrusions in gastric ulcer disease.
Hum Pathol. 1997 Oct;28(10):1126-30. doi: 10.1016/s0046-8177(97)90249-5.
2
Gastric corpus IL-8 concentration and neutrophil infiltration in duodenal ulcer patients.
Aliment Pharmacol Ther. 1997 Aug;11(4):793-800. doi: 10.1046/j.1365-2036.1997.00218.x.
3
Gastric mucosa during treatment with lansoprazole: Helicobacter pylori is a risk factor for argyrophil cell hyperplasia.
Gastroenterology. 1997 Mar;112(3):707-17. doi: 10.1053/gast.1997.v112.pm9041231.
4
Current European concepts in the management of Helicobacter pylori infection--the Maastricht Consensus Report. The European Helicobacter Pylori Study Group (EHPSG).
Eur J Gastroenterol Hepatol. 1997 Jan;9(1):1-2. doi: 10.1097/00042737-199701000-00002.
5
Omeprazole produces parietal cell hypertrophy and hyperplasia in humans.
Dig Dis Sci. 1996 Oct;41(10):2039-47. doi: 10.1007/BF02093608.
6
Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994.
Am J Surg Pathol. 1996 Oct;20(10):1161-81. doi: 10.1097/00000478-199610000-00001.
7
Effect of proton pump inhibitors on the detection of Helicobacter pylori in gastric biopsies.
Aliment Pharmacol Ther. 1996 Jun;10(3):289-93. doi: 10.1111/j.0953-0673.1996.00289.x.
8
Helicobacter pylori and gastric cancer.
Scand J Gastroenterol Suppl. 1996;215:48-51.
9
Recognizing atrophy: another step toward a classification of gastritis.
Am J Surg Pathol. 1996;20 Suppl 1:S23-30. doi: 10.1097/00000478-199600001-00004.
10
Helicobacter pylori in the stomach--a paradox unmasked.
N Engl J Med. 1996 Jul 25;335(4):278-80. doi: 10.1056/NEJM199607253350411.
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