Arnaud M J
Experientia. 1976 Oct 15;32(10):1238-40. doi: 10.1007/BF01953069.
[1-CH3-14C] 1,3,7-trimethyldihydrouric acid which, in quantity, is the most important caffeine metabolite, was isolated and purified from the urine of rats fed with [1-CH3-14C] caffeine. The oral administration of this metabolite to rats showed that 1,3,7-trimethyldihydrouric acid was excreted unchanged in urine and was therefore an end product of caffeine metabolism. This result implies a new metabolic pathway of caffeine.
[1-CH3-14C] 1,3,7-三甲基二氢尿酸是咖啡因最重要的代谢产物，从喂食[1-CH3-14C]咖啡因的大鼠尿液中分离并纯化得到。给大鼠口服这种代谢产物后发现，1,3,7-三甲基二氢尿酸以原形经尿液排出，因此是咖啡因代谢的终产物。这一结果暗示了咖啡因一种新的代谢途径。
