• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Synthesis and pharmacological properties of some quinoline derivatives.

作者信息

Kalluraya B, Sreenivasa S

机构信息

Department of Studies in Chemistry, Mangalore University, Karnataka State, India.

出版信息

Farmaco. 1998 Jun 30;53(6):399-404. doi: 10.1016/s0014-827x(98)00037-8.

DOI:10.1016/s0014-827x(98)00037-8
PMID:9764472
Abstract

A series of 2-(2-thienyl) cinchoninic acids 3, their derivatives 5 and 4-(3-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazolo-6-yl)-2-( 2-thienyl) quinolines 6 were synthesized. The structures of the newly synthesized compounds are confirmed by analytical, IR, NMR and mass spectral data. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anthelmintic activity. The results indicated that dinitrothiophene derivatives 5 are more active.

摘要

相似文献

1
Synthesis and pharmacological properties of some quinoline derivatives.
Farmaco. 1998 Jun 30;53(6):399-404. doi: 10.1016/s0014-827x(98)00037-8.
2
Synthesis, Characterization & Screening for Anti-Inflammatory & Analgesic Activity of Quinoline Derivatives Bearing Azetidinones Scaffolds.含氮杂环丁酮骨架喹啉衍生物的合成、表征及其抗炎和镇痛活性筛选
Antiinflamm Antiallergy Agents Med Chem. 2016;15(1):31-43. doi: 10.2174/1871523015666160210124545.
3
Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives of isoniazid.异烟肼缩杂环 6-取代 1,2,4-三唑并[3,4-b]-1,3,4-噻二唑和 1,3,4-噁二唑衍生物的合成与药理学评价。
Bioorg Med Chem Lett. 2010 Aug 15;20(16):4762-5. doi: 10.1016/j.bmcl.2010.06.125. Epub 2010 Jun 27.
4
Novel dihydropyrimidines and its pyrazole derivatives: synthesis and pharmacological screening.新型二氢嘧啶类及其吡唑衍生物的合成与药理筛选。
Eur J Med Chem. 2011 May;46(5):1882-91. doi: 10.1016/j.ejmech.2011.02.052. Epub 2011 Feb 26.
5
Synthesis, anti-inflammatory and analgesic activity of some new 4(3H)-quinazolinone derivatives.一些新型4(3H)-喹唑啉酮衍生物的合成、抗炎及镇痛活性
Arch Pharm (Weinheim). 2004 Feb;337(2):96-104. doi: 10.1002/ardp.200200752.
6
Synthesis and biological activity studies of 1,3,4-thiadiazolo[2,3-c]-as-triazines.
Boll Chim Farm. 1997 Mar;136(3):266-71.
7
Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents.作为新型抗炎和镇痛药的吡唑啉衍生物的合成及药理评价
Bioorg Med Chem Lett. 2008 Feb 1;18(3):918-22. doi: 10.1016/j.bmcl.2007.12.043. Epub 2008 Jan 7.
8
Synthesis, anti-inflammatory and analgesic evaluation of certain new 3a,4,9,9a-tetrahydro-4,9-benzenobenz[f]isoindole-1,3-diones.某些新型 3a,4,9,9a-四氢-4,9-亚苯基苯并[f]异吲哚-1,3-二酮的合成、抗炎和镇痛评价。
Arch Pharm (Weinheim). 2011 Aug;344(8):543-51. doi: 10.1002/ardp.201100020. Epub 2011 Jun 16.
9
A comprehensive review on the biological interest of quinoline and its derivatives.喹啉及其衍生物的生物学研究进展综述
Bioorg Med Chem. 2021 Feb 15;32:115973. doi: 10.1016/j.bmc.2020.115973. Epub 2020 Dec 31.
10
Synthesis of novel 4-substituted-7-trifluoromethylquinoline derivatives with nitric oxide releasing properties and their evaluation as analgesic and anti-inflammatory agents.具有一氧化氮释放特性的新型4-取代-7-三氟甲基喹啉衍生物的合成及其作为镇痛和抗炎剂的评价。
Bioorg Med Chem. 2005 Oct 15;13(20):5759-65. doi: 10.1016/j.bmc.2005.05.053.

引用本文的文献

1
Quinoline Quest: Kynurenic Acid Strategies for Next-Generation Therapeutics via Rational Drug Design.喹啉探索:通过合理药物设计开发下一代治疗药物的犬尿喹啉酸策略
Pharmaceuticals (Basel). 2025 Apr 22;18(5):607. doi: 10.3390/ph18050607.
2
2-(4-Methyl-phen-yl)quinoline-4-carb-oxy-lic acid.2-(4-甲基苯基)喹啉-4-羧酸
Acta Crystallogr Sect E Struct Rep Online. 2012 Oct 1;68(Pt 10):o2892. doi: 10.1107/S160053681203797X. Epub 2012 Sep 8.
3
9-(Thio-phen-2-yl)-8,9-dihydro-3H-pyrazolo-[4,3-f]quinolin-7(6H)-one ethanol monosolvate.
9-(噻吩-2-基)-8,9-二氢-3H-吡唑并[4,3-f]喹啉-7(6H)-酮乙醇单溶剂合物
Acta Crystallogr Sect E Struct Rep Online. 2012 Sep 1;68(Pt 9):o2608. doi: 10.1107/S1600536812033533. Epub 2012 Aug 1.
4
(E)-1-(2,4-Dimethyl-quinolin-3-yl)-3-(4-methyl-phen-yl)prop-2-en-1-one.(E)-1-(2,4-二甲基喹啉-3-基)-3-(4-甲基苯基)丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2012 May 1;68(Pt 5):o1501. doi: 10.1107/S1600536812015498. Epub 2012 Apr 21.
5
(2E)-1-(2,4-Dimethyl-quinolin-3-yl)-3-(thio-phen-2-yl)prop-2-en-1-one.(2E)-1-(2,4-二甲基喹啉-3-基)-3-(噻吩-2-基)丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Sep 1;67(Pt 9):o2283-4. doi: 10.1107/S1600536811031485. Epub 2011 Aug 11.
6
1-(6,8-Dibromo-2-methyl-quinolin-3-yl)ethanone.1-(6,8-二溴-2-甲基喹啉-3-基)乙酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2664. doi: 10.1107/S1600536811037044. Epub 2011 Sep 17.
7
(2E)-3-(4-Chloro-phen-yl)-1-(2,4-dimethyl-quinolin-3-yl)prop-2-en-1-one.(2E)-3-(4-氯苯基)-1-(2,4-二甲基喹啉-3-基)丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 1;67(Pt 4):o796-7. doi: 10.1107/S1600536811007835. Epub 2011 Mar 5.
8
2-(2,4-Dichloro-phen-yl)-9-phenyl-2,3-di-hydro-thieno[3,2-b]quinoline.2-(2,4-二氯苯基)-9-苯基-2,3-二氢噻吩并[3,2-b]喹啉
Acta Crystallogr Sect E Struct Rep Online. 2009 Jul 4;65(Pt 8):o1783. doi: 10.1107/S1600536809025380.
9
1-(6-Chloro-2-methyl-4-phenyl-quinolin-3-yl)-3-(3-methoxy-phen-yl)prop-2-en-1-one.
Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 9;66(Pt 1):o91-2. doi: 10.1107/S1600536809052179.
10
(E)-1-(6-Chloro-2-methyl-4-phenyl-3-quinol-yl)-3-(2-methoxy-phen-yl)prop-2-en-1-one.(E)-1-(6-氯-2-甲基-4-苯基-3-喹啉基)-3-(2-甲氧基苯基)-2-丙烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2010 Jan 13;66(Pt 2):o353-4. doi: 10.1107/S1600536810000784.