Poggi S H, Bristow R E, Nieberg R K, Berek J S
Department of Obstetrics and Gynecology, UCLA School of Medicine, Los Angeles, California 90027, USA.
Obstet Gynecol. 1998 Oct;92(4 Pt 2):659-61. doi: 10.1016/s0029-7844(98)00028-3.
Psammocarcinoma is an unusual variant of serous cystadenocarcinoma characterized by heavy deposits of psammoma bodies. This disease has been suggested to be similar to carcinomas of low malignant potential in its indolent clinical course. We present this case report of an aggressive course of this disease to alert others that psammocarcinoma may not always follow a benign course.
A 66-year-old woman underwent staging laparotomy for bilateral ovarian cystadenofibromata with rare foci of borderline serous tumors and several small bowel peritoneal surface nodules showing infiltrating psammocarcinoma. She was not recommended for adjuvant therapy because of the previously reported indolent course of this disease. Eighteen months later she represented with small bowel obstruction and underwent an exploratory laparotomy that demonstrated diffuse recurrence of the psammocarcinoma.
Psammocarcinoma may have a more aggressive course than has been suggested. Patients with this disease should have optimal tumor debulking. There may be a role for adjuvant therapy in its treatment.
砂粒体癌是浆液性囊腺癌的一种罕见变体，其特征为大量砂粒体沉积。有人认为这种疾病在临床病程缓慢方面类似于低恶性潜能癌。我们报告该疾病侵袭性病程的这一病例，以提醒其他人砂粒体癌不一定总是良性病程。
一名66岁女性因双侧卵巢囊腺纤维瘤伴罕见的交界性浆液性肿瘤灶以及多个显示浸润性砂粒体癌的小肠腹膜表面结节接受分期剖腹手术。由于此前报道的该疾病病程缓慢，未建议她接受辅助治疗。18个月后，她因小肠梗阻就诊并接受了探查性剖腹手术，结果显示砂粒体癌弥漫性复发。
砂粒体癌的病程可能比此前认为的更具侵袭性。患有这种疾病的患者应进行最佳的肿瘤减瘤手术。辅助治疗在其治疗中可能有作用。
