Antonini R, Turner T T, Pauerstein C J
Fertil Steril. 1976 Nov;27(11):1322-5. doi: 10.1016/s0015-0282(16)42203-x.
Forty guinea pigs were divided into two groups, pregnant and nonpregnant, and were operated upon on days 10, 12, 14, and 16 of the ovarian cycle or of pregnancy. Blood was obtained from the utero-ovarian vein, and prostaglandin F2alpha (PGF2alpha), prostaglandin E (PGE), progesterone, and estrogen content was assayed by radioimmunoassay. Increased levels of PGF2alpha preceded a drop in progesterone levels in nonpregnant animals, reflecting luteolysis. In pregnant animals, the level of PGF2alpha remained low, and progesterone levels increased. PGE levels were similar in the two groups. These results suggest that the low PGF2alpha levels seen during early pregnancy are related to corpus luteum rescue.
40只豚鼠被分为两组，即怀孕组和未怀孕组，并在卵巢周期或怀孕期间的第10、12、14和16天进行手术。从子宫卵巢静脉取血，通过放射免疫分析法测定前列腺素F2α（PGF2α）、前列腺素E（PGE）、孕酮和雌激素含量。在未怀孕的动物中，PGF2α水平升高先于孕酮水平下降，这反映了黄体溶解。在怀孕的动物中，PGF2α水平保持较低，而孕酮水平升高。两组中的PGE水平相似。这些结果表明，怀孕早期出现的低PGF2α水平与黄体挽救有关。
