在无菌乳鼠中建立用于轮状病毒腹泻研究的异种模型。
Development of a heterologous model in germfree suckling rats for studies of rotavirus diarrhea.
作者信息
Guerin-Danan C, Meslin J C, Lambre F, Charpilienne A, Serezat M, Bouley C, Cohen J, Andrieux C
机构信息
Unité d'Ecologie et de Physiologie du Système Digestif, Equipe Métabolites Bactériens et Santé, INRA, 78352 Jouy-en-Josas Cedex, France.
出版信息
J Virol. 1998 Nov;72(11):9298-302. doi: 10.1128/JVI.72.11.9298-9302.1998.
Abstract
Germfree suckling rats were infected with an SA11 rotavirus strain. Infected pups developed diarrhea associated with histopathological changes. The virus was detected in feces and in the small intestine. Cellular vacuolation was observed in the villi of the jejunum. These results provide a new model for further investigations of group A rotavirus infection.
摘要
无菌乳鼠感染了SA11轮状病毒株。受感染的幼鼠出现腹泻并伴有组织病理学变化。在粪便和小肠中检测到该病毒。在空肠绒毛中观察到细胞空泡化。这些结果为进一步研究A组轮状病毒感染提供了一个新模型。
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