人淋巴组织中离体的CD4(+) T淋巴细胞耗竭并非由非感染性1型人类免疫缺陷病毒颗粒诱导产生。
CD4(+) T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions.
作者信息
Sylwester A W, Grivel J C, Fitzgerald W, Rossio J L, Lifson J D, Margolis L B
机构信息
Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1855, USA.
出版信息
J Virol. 1998 Nov;72(11):9345-7. doi: 10.1128/JVI.72.11.9345-9347.1998.
Abstract
We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4(+) T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4(+) T-cell depletion, consistent with mechanisms requiring productive infection.
摘要
我们测试了1型人类免疫缺陷病毒（HIV-1）、无感染性但构象真实的灭活全HIV-1病毒体以及纯化的gp120在体外诱导人淋巴组织中CD4(+) T细胞耗竭的能力。具有感染性的趋化因子受体4（CXCR4）嗜性HIV-1介导了CD4(+) T细胞的耗竭，而匹配的灭活病毒体或gp120则不能，这与需要有效感染的机制一致。
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本文引用的文献
1
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J Virol. 1998 Oct;72(10):7992-8001. doi: 10.1128/JVI.72.10.7992-8001.1998.
2
Evidence for the HIV-1 phenotype switch as a causal factor in acquired immunodeficiency.人类免疫缺陷病毒1型（HIV-1）表型转换作为获得性免疫缺陷病因的证据。
Nat Med. 1998 Mar;4(3):346-9. doi: 10.1038/nm0398-346.
3
A new classification for HIV-1.一种针对HIV-1的新分类法。
Nature. 1998 Jan 15;391(6664):240. doi: 10.1038/34571.
4
Experimental HIV infection of human lymphoid tissue: correlation of CD4+ T cell depletion and virus syncytium-inducing/non-syncytium-inducing phenotype in histocultures inoculated with laboratory strains and patient isolates of HIV type 1.人类淋巴组织的实验性HIV感染：接种1型HIV实验室毒株和患者分离株的组织培养物中CD4 + T细胞耗竭与病毒合胞体诱导/非合胞体诱导表型的相关性
AIDS Res Hum Retroviruses. 1997 Apr 10;13(6):461-71. doi: 10.1089/aid.1997.13.461.
5
Mechanisms of lymphocyte killing by HIV.HIV杀伤淋巴细胞的机制。
Curr Opin Hematol. 1997 Jan;4(1):24-31. doi: 10.1097/00062752-199704010-00005.
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7
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AIDS. 1996 Jun;10(6):603-11. doi: 10.1097/00002030-199606000-00005.
8
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9
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10
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