Nagano M, Uike N, Suzumiya J, Muta K, Goto T, Suehiro Y, Choi I, Yufu Y, Taniguchi J, Kikuchi M, Kozuru M
Department of Hematology, National Kyushu Cancer Center, Fukuoka University, Japan.
Am J Hematol. 1998 Oct;59(2):171-4. doi: 10.1002/(sici)1096-8652(199810)59:2<171::aid-ajh12>3.0.co;2-c.
A patient with primary cardiac lymphoma, which is very rare, generally is regarded to have a poor prognosis. We herein report a patient with cardiac lymphoma who was treated successfully by systemic chemotherapy and radiotherapy using a pacemaker to control the complete atrioventricular (A-V) block. A 70-year-old man had a syncope caused by a complete A-V block. An echocardiogram, a computed tomographic scan, and magnetic resonance imaging of his chest showed a cardiac tumor. At this time, a biopsy of the cardiac tumor disclosed malignant lymphoma (diffuse large cell type, B cell type). The patient was thus treated with systemic chemotherapy and radiotherapy and, as a result, achieved a complete remission with a disappearance of the A-V block. Recently, several successful outcomes involving primary cardiac lymphoma have been reported because of the progress in diagnostic techniques including echocardiography, computed tomographic scanning, and magnetic resonance imaging, as well as improvement in the therapy of malignant lymphoma. Our clinical experience indicated that an early and accurate diagnosis combined with the appropriate therapy can thus help in obtaining a long survival in patients with primary cardiac lymphoma.
原发性心脏淋巴瘤患者非常罕见，一般认为预后较差。我们在此报告一例心脏淋巴瘤患者，通过全身化疗和放疗，并使用起搏器控制完全性房室传导阻滞，成功治愈。一名70岁男性因完全性房室传导阻滞导致晕厥。其超声心动图、胸部计算机断层扫描和磁共振成像显示有心脏肿瘤。此时，心脏肿瘤活检显示为恶性淋巴瘤（弥漫大细胞型，B细胞型）。该患者因此接受了全身化疗和放疗，结果实现了完全缓解，房室传导阻滞消失。近来，由于超声心动图、计算机断层扫描和磁共振成像等诊断技术的进步以及恶性淋巴瘤治疗的改善，已有几例原发性心脏淋巴瘤治疗成功的报道。我们的临床经验表明，早期准确诊断并结合适当治疗有助于原发性心脏淋巴瘤患者获得长期生存。
