Levin B E, Govek E K, Dunn-Meynell A A
Neurology Service (127C), VA Medical Center, 385 Tremont Avenue, East Orange, NJ 07018-1095, USA.
Brain Res. 1998 Oct 19;808(2):317-9. doi: 10.1016/s0006-8993(98)00839-7.
Rats predisposed to develop diet-induced obesity (DIO) preferentially activate their sympathetic nervous system during intracarotid glucose infusion [B.E. Levin, Intracarotid glucose-induced norepinephrine response and the development of diet-induced obesity, Int. J. Obesity 16 (1992) 451-457.] but their brains are generally less responsive to glucose than diet-resistant rats (DR) [B.E. Levin, K.L. Brown, A.A. Dunn-Meynell, Differential effects of diet and obesity on high and low affinity sulfonylurea binding sites in the rat brain, Brain Res. 739 (1996) 293-300.; B.E. Levin, B. Planas, Defective glucoregulation of brain alpha2-adrenoceptors in obesity-prone rats, Am. J. Physiol. 264 (1993) R305-R311.; B.E. Levin, A.C. Sullivan, Glucose-induced norepinephrine levels and obesity resistance, Am. J. Physiol. 253 (1987) R475-R481.; B.E. Levin, A.C. Sullivan, Glucose-induced sympathetic activation in obesity-prone and resistant rats, Int. J. Obesity 13 (1989) 235-246.]. Here, 1 h intracarotid glucose infusions (4 mg/kg/min) selectively increased Fos-like immunoreactivity (FLIR) in the hypothalamic paraventricular, ventromedial, dorsomedial and arcuate nuclei of inbred DR but not DIO rats. This suggests that enhanced glucose-induced sympathetic activation in DIO rats is related to a failure of glucose to produce neuronal activation in these areas.
易患饮食诱导性肥胖（DIO）的大鼠在颈内动脉输注葡萄糖期间优先激活其交感神经系统[B.E. 莱文，《颈内动脉葡萄糖诱导的去甲肾上腺素反应与饮食诱导性肥胖的发展》，《国际肥胖杂志》16（1992）451 - 457]，但其大脑对葡萄糖的反应通常比抗饮食性肥胖大鼠（DR）弱[B.E. 莱文，K.L. 布朗，A.A. 邓恩 - 梅内尔，《饮食和肥胖对大鼠大脑中高亲和力和低亲和力磺酰脲结合位点的不同影响》，《脑研究》739（1996）293 - 300；B.E. 莱文，B. 普拉纳斯，《易肥胖大鼠大脑α2 - 肾上腺素能受体的葡萄糖调节缺陷》，《美国生理学杂志》264（1993）R305 - R311；B.E. 莱文，A.C. 沙利文，《葡萄糖诱导的去甲肾上腺素水平与肥胖抗性》，《美国生理学杂志》253（1987）R475 - R481；B.E. 莱文，A.C. 沙利文，《易肥胖和抗性大鼠中葡萄糖诱导的交感神经激活》，《国际肥胖杂志》13（1989）235 - 246]。在此，1小时的颈内动脉葡萄糖输注（4毫克/千克/分钟）选择性地增加了近交系DR大鼠而非DIO大鼠下丘脑室旁核、腹内侧核、背内侧核和弓状核中的Fos样免疫反应性（FLIR）。这表明DIO大鼠中增强的葡萄糖诱导的交感神经激活与葡萄糖未能在这些区域产生神经元激活有关。
