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巴西蝎毒(Tityus serrulatus Lutz e Mello)毒素诱导的超敏反应。

Supersensitivity induced by the toxin of Brazilian scorpion venom (Tityus serrulatus Lutz e Mello).

作者信息

Antonio A, Melito I, Almeida A P, Corrado A P

出版信息

Gen Pharmacol. 1976 Aug;7(2-3):111-4. doi: 10.1016/0306-3623(76)90045-8.

DOI:10.1016/0306-3623(76)90045-8
PMID:976729
Abstract

The purified toxin of the Brazilian scorpion venom (TsTX) enhances the pharmacological actions of directly and indirectly acting substances on several preparations. The enhancing action of TsTX is more pronounced for the indirectly acting drugs, which is highly suggestive of a prejunctional site of action. Secondarily, TsTX does also produce an unspecific increase of sensitivity at the level of the pharmacological receptor itself. The mechanism by which these changes are brought about remains to be determined.

摘要

巴西蝎子毒液的纯化毒素(TsTX)可增强直接和间接作用物质对多种制剂的药理作用。TsTX对间接作用药物的增强作用更为显著,这强烈提示其作用位点在神经节前。其次,TsTX确实也会在药理受体自身水平非特异性地增加敏感性。这些变化产生的机制仍有待确定。

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1
Supersensitivity induced by the toxin of Brazilian scorpion venom (Tityus serrulatus Lutz e Mello).巴西蝎毒(Tityus serrulatus Lutz e Mello)毒素诱导的超敏反应。
Gen Pharmacol. 1976 Aug;7(2-3):111-4. doi: 10.1016/0306-3623(76)90045-8.
2
Supersensitivity of the isolated guinea-pig vas deferens induced by a toxic fraction of scorpion venom (Tityus serrulatus).由蝎毒(巴西金幽灵蝎)的有毒成分诱导的豚鼠离体输精管超敏反应。
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;78(1):171-3. doi: 10.1016/0742-8413(84)90065-3.
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Prejunctional effects of a purified toxin from the scorpion Tityus serrulatus: release of 3H-noradrenaline and enhancement of transmitter overflow elicited by nerve stimulation.巴西金幽灵蝎纯化毒素的接头前效应:3H-去甲肾上腺素的释放及神经刺激引起的递质溢出增强
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Prejunctional supersensitization of adrenergic transmission of the isolated guinea pig vas deferens produced by an atoxic fraction from scorpion venom (Tityus serrulatus).由蝎子毒液(锯齿脂鲤蝎)的无毒组分所产生的豚鼠离体输精管肾上腺素能传递的接头前超敏化作用。
Braz J Med Biol Res. 1983 Jul;16(2):147-51.
5
Further characterization of toxins T1IV (TsTX-III) and T2IV from Tityus serrulatus scorpion venom.对来自锯齿蝎毒液的毒素T1IV(TsTX-III)和T2IV的进一步特性分析。
Toxicon. 1991;29(6):663-72. doi: 10.1016/0041-0101(91)90058-y.
6
Selective release of ATP from sympathetic nerves of rat vas deferens by the toxin TsTX-I from Brazilian scorpion Tityus serrulatus.巴西锯齿脂鲤(Tityus serrulatus)的毒素TsTX-I从大鼠输精管的交感神经中选择性释放ATP 。
Br J Pharmacol. 2005 Feb;144(4):519-27. doi: 10.1038/sj.bjp.0706062.
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The mechanism of the hypertensive effect of Brazilian scorpion venom (Tityus serrulatus Lutz E Mello).
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A simplified procedure for the fractionation of Tityus serrulatus venom: isolation and partial characterization of TsTX-IV, a new neurotoxin.一种简化的巴西游走蛛毒液分级分离程序:新型神经毒素TsTX-IV的分离与部分特性鉴定
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Antigenic cross-reactivity among the venoms from several species of Brazilian scorpions.几种巴西蝎子毒液之间的抗原交叉反应性。
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The complete amino acid sequence of toxin TsTX-VI isolated from the venom of the scorpion Tityus serrulatus.从锯尾蝎毒液中分离出的毒素TsTX-VI的完整氨基酸序列。
J Protein Chem. 1990 Oct;9(5):595-601. doi: 10.1007/BF01025013.