Schmitt U M, Stieber P, Jüngst D, Bilzer M, Wächtler M, Heberger S, Seidel D
Klinikum Grosshadern, Ludwig-Maximilians-University Munich, Germany.
Eur J Clin Invest. 1998 Aug;28(8):615-21. doi: 10.1046/j.1365-2362.1998.00343.x.
The role of carbohydrate-deficient transferrin (CDT) as a reliable marker for the detection of chronic alcohol abuse has been discussed controversially.
Therefore, we investigated CDT in the sera from 405 subjects with different alcohol intake. Besides healthy control subjects (n = 42), inpatients and outpatients in a department of gastroenterology (n = 325) and patients admitted to a department of otorhinolaryngology (n = 38) were studied. A total of 213 patients suffered from various forms of liver diseases, and 89 patients had liver transplantation. CDT values were determined by a double-antibody radioimmunoassay.
In the 241 alcohol-abstinent subjects, CDT levels ranged from 3 to 90 units L-1 (median = 12); the 92 moderate drinkers (20-60 g of alcohol per day) showed values from 3 to 40 units L-1 (median = 12), and the 72 subjects with chronic alcohol abuse (> 60 g per day) revealed CDT levels from 3 to 100 units L-1 (median = 16). The diagnostic specificity for alcohol abuse was 86.8% for men (sensitivity 36.9%) and 95% for women (sensitivity 0%).
Our data indicate that measurement of CDT does not reach clinical use in the detection of chronic alcohol abuse in an unselected population because of its insufficient specificity and sensitivity.
缺糖转铁蛋白（CDT）作为检测慢性酒精滥用的可靠标志物，其作用一直存在争议。
因此，我们对405名饮酒量不同的受试者血清中的CDT进行了研究。除了健康对照者（n = 42）外，还研究了胃肠病科的住院和门诊患者（n = 325）以及耳鼻喉科收治的患者（n = 38）。共有213例患者患有各种形式的肝病，89例患者接受了肝移植。CDT值通过双抗体放射免疫测定法测定。
在241名戒酒者中，CDT水平在3至90单位L-1之间（中位数 = 12）；92名中度饮酒者（每天饮酒20 - 60克）的CDT值在3至40单位L-1之间（中位数 = 12），72名慢性酒精滥用者（每天饮酒> 60克）的CDT水平在3至100单位L-1之间（中位数 = 16）。男性酒精滥用的诊断特异性为86.8%（敏感性为36.9%），女性为95%（敏感性为0%）。
我们的数据表明，由于CDT的特异性和敏感性不足，在未经过筛选的人群中，测量CDT在检测慢性酒精滥用方面尚未达到临床应用的要求。
