脂多糖诱导的肿瘤坏死因子和白细胞介素-1的产生在受体水平受到不同调节：CD14依赖性和CD14非依赖性途径的作用。
Lipopolysaccharide-induced production of tumour necrosis factor and interleukin-1 is differentially regulated at the receptor level: the role of CD14-dependent and CD14-independent pathways.
作者信息
Netea M G, Kullberg B J, van der Meer J W
机构信息
Department of Medicine, University Hospital Nijmegen, The Netherlands.
出版信息
Immunology. 1998 Jul;94(3):340-4. doi: 10.1046/j.1365-2567.1998.00532.x.
Abstract
Cytokine production induced via CD14-dependent and CD14-independent pathways was investigated in mouse peritoneal macrophages incubated with lipopolysaccharide (LPS) or lipid A. Different LPS receptors appear to be responsible for production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha) and IL-1 beta. TNF-alpha production is essentially CD14 dependent, both in the presence or absence of plasma. In the presence of plasma, endotoxin-induced IL-1 production is mediated by CD14-dependent mechanisms, while in its absence both CD14-dependent and CD14-independent pathways are involved. Lipid A stimulates cytokine synthesis through both CD14-dependent and CD14-independent mechanisms, but its action is weaker than that of LPS, indicating that the polysaccharide moiety may be necessary for proper stimulation of mouse macrophages by endotoxin.
摘要
在用脂多糖（LPS）或脂质A孵育的小鼠腹腔巨噬细胞中，研究了通过CD14依赖性和CD14非依赖性途径诱导的细胞因子产生。不同的LPS受体似乎负责肿瘤坏死因子-α（TNF-α）、白细胞介素-1α（IL-1α）和IL-1β的产生。TNF-α的产生基本上依赖于CD14，无论有无血浆。在有血浆的情况下，内毒素诱导的IL-1产生由CD14依赖性机制介导，而在无血浆的情况下，CD14依赖性和CD14非依赖性途径均参与其中。脂质A通过CD14依赖性和CD14非依赖性机制刺激细胞因子合成，但其作用比LPS弱，表明多糖部分可能是内毒素适当刺激小鼠巨噬细胞所必需的。
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