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[呼吸道合胞病毒补体结合抗体的测定。哈瓦那市1岁以下人群的纵向研究]

[Determination of complement-fixing antibodies to respiratory syncytial virus. Longitudinal study in a population of less than 1 year of age in the City of Havana].

作者信息

Goyenechea A, Bello M, Clua A, Savón C, Valdivia A, Oropesa S, Díaz O, Hernández B

机构信息

Instituto de Medicina Tropical Pedro Kouri.

出版信息

Rev Cubana Med Trop. 1994;46(2):79-85.

PMID:9768240
Abstract

Respiratory syncytial viruses (RSV) are considered among the most important agents causing acute respiratory infections in infants below 1 year of age. A 10-year longitudinal study of monosera from children under 15 years was carried out; 1,069 monosera from children under 1 year were studied using the RSV antigen complement-fixing technique. It was observed that there were short or longer periods between the peaks of positive sera and when they were compared with medical care reports, they showed correspondence with increased numbers of medical care reports. A typical seasonal pattern in the distribution of antibodies was determined and this corresponded to the month of February, suggesting that this is probably due to the circulation of the virus and not to maternal antibodies. The results attained give grounds for considering the possible circulation of RSV in our country.

摘要

呼吸道合胞病毒(RSV)被认为是导致1岁以下婴儿急性呼吸道感染的最重要病原体之一。对15岁以下儿童的单份血清进行了为期10年的纵向研究;使用RSV抗原补体结合技术对1岁以下儿童的1069份单份血清进行了研究。观察到阳性血清峰值之间存在短期或长期的间隔,当将它们与医疗报告进行比较时,它们显示出与医疗报告数量增加相对应。确定了抗体分布的典型季节性模式,这与2月份相对应,表明这可能是由于病毒的传播而不是母体抗体所致。所获得的结果为考虑RSV在我国可能的传播提供了依据。

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Rev Cubana Med Trop. 1994;46(2):79-85.
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引用本文的文献

1
Unusual antigenic and genetic characteristics of human respiratory syncytial viruses isolated in Cuba.在古巴分离出的人类呼吸道合胞病毒的异常抗原和基因特征。
J Virol. 1998 Sep;72(9):7589-92. doi: 10.1128/JVI.72.9.7589-7592.1998.