Ross B D, Bluml S, Cowan R, Danielsen E, Farrow N, Tan J
MR Spectroscopy Unit, Huntington Medical Research Institute, Pasadena 91105, USA.
Neuroimaging Clin N Am. 1998 Nov;8(4):809-22.
Nuclear MR spectroscopy in low and medium magnetic fields yields well-resolved natural abundance proton and decoupled phosphorus spectra from small (1-10 mL) volumes of brain in vivo in minutes. With this tool, neurochemical research has advanced through identification and noninvasve assay of a specific neuronal-cf2Ncf1-acetylaspartate, glial (cf2myocf1-inositol)-markers, energetics and osmolutes, and neurotransmitters (glutamate, GABA). From these simple measurements, several dozen disease states are recognized, including birth injury, and white matter and Alzheimer disease. Together, these tools are having a major impact on neuroscience and clinical medicine.
低磁场和中磁场下的核磁共振波谱能够在数分钟内，从活体中体积较小（1 - 10毫升）的脑区获得分辨率良好的天然丰度质子谱以及去耦磷谱。借助这一工具，神经化学研究取得了进展，通过对特定神经元标志物N-乙酰天门冬氨酸、胶质细胞标志物（肌醇）、能量代谢物和渗透溶质以及神经递质（谷氨酸、γ-氨基丁酸）进行识别和无创检测。通过这些简单测量，已识别出几十种疾病状态，包括出生损伤、白质病变和阿尔茨海默病。这些工具共同对神经科学和临床医学产生了重大影响。
