苯妥英对猪五肽胃泌素刺激的降钙素分泌的抑制作用。
Diphenylhydantoin inhibition of pentagastrin-stimulated calcitonin secretion in the pig.
作者信息
Pento J T
出版信息
Horm Metab Res. 1976 Sep;8(5):399-401. doi: 10.1055/s-0028-1093603.
PMID:976938
Abstract
The present study examined the influence of diphenylhydantoin (DPH) on pentagastrin-induced calcitonin (CT) secretion in the pig. Diphenylhydantoin was observed to slow the onset and prolong the duration of pentagastrin stimulation on CT secretion. Further, pentagastrin reduced plasma calcium in both the control and DPH treated groups. The results of this study indicate a significant DPH-induced inhibition of pentagastrin-stimulated CT secretion in the pig.
摘要
本研究检测了苯妥英（DPH）对猪体内五肽胃泌素诱导的降钙素（CT）分泌的影响。观察到苯妥英可减缓五肽胃泌素对CT分泌刺激的起始，并延长其持续时间。此外，五肽胃泌素在对照组和DPH处理组中均降低了血浆钙水平。本研究结果表明，在猪体内，苯妥英可显著抑制五肽胃泌素刺激的CT分泌。
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