Radsak K, Weissbach A
Hoppe Seylers Z Physiol Chem. 1976 Aug;357(8):1103-7. doi: 10.1515/bchm2.1976.357.2.1103.
HeLa cells exposed to chloramphenicol for approximately one cell generation were found to contain a mitochondria-associated DNA polymerase with a significantly lower specific activity than that of control cells. This observation was not due to the presence of inhibitors in mitochondrial DNA polymerase preparations of chloramphenicol-treated cell cultures. In addition, there was no accumulation of a typical mitochondrial DNA polymerase in the post-mitochondrial supernatant of drug-treated cells.
在大约一个细胞世代中暴露于氯霉素的海拉细胞被发现含有一种与线粒体相关的DNA聚合酶，其比对照细胞的比活性显著更低。该观察结果并非由于氯霉素处理的细胞培养物的线粒体DNA聚合酶制剂中存在抑制剂。此外，在药物处理细胞的线粒体后上清液中没有典型线粒体DNA聚合酶的积累。
