Adamson A J, Rand S D, Prost R W, Kim T A, Schultz C, Haughton V M
Department of Radiology, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee 53226, USA.
Radiology. 1998 Oct;209(1):73-8. doi: 10.1148/radiology.209.1.9769815.
To determine the influence of single-voxel proton magnetic resonance (MR) spectroscopic findings on the treatment of patients suspected of having a brain tumor.
Medical records were reviewed in 78 patients who underwent MR spectroscopy for evaluation of a focal brain mass suspected of being neoplastic. MR spectroscopic findings were positive for neoplasm in 49 patients and negative in 29. Treatment with or without performance of biopsy was noted. In patients with positive findings who underwent irradiation or chemotherapy without biopsy and in patients with negative findings who were treated medically or followed up for interval changes, MR spectroscopy was classified as having a potential positive influence on treatment. In patients with positive findings with subsequently proved nonneoplastic lesions and in patients with negative findings with subsequently proved tumors, MR spectroscopy was classified as having a potential negative influence.
MR spectroscopy in eight (16%) patients with positive findings and in 15 (52%) patients with negative findings had a potential positive influence on treatment. In two (3%) patients, MR spectroscopy had a potential negative influence.
MR spectroscopy may play a beneficial role in the management of suspected brain tumors. Prospective studies are needed to test the effect of MR spectroscopy on clinical practice and to measure costs and benefits.
确定单体素质子磁共振（MR）波谱分析结果对疑似脑肿瘤患者治疗的影响。
回顾了78例因疑似肿瘤性局灶性脑肿块而接受MR波谱分析的患者的病历。49例患者的MR波谱分析结果显示肿瘤阳性，29例为阴性。记录了是否进行活检的治疗情况。在未进行活检而接受放疗或化疗的阳性结果患者以及接受药物治疗或随访观察病情变化的阴性结果患者中，MR波谱分析被归类为对治疗有潜在积极影响。在阳性结果随后被证明为非肿瘤性病变的患者以及阴性结果随后被证明为肿瘤的患者中，MR波谱分析被归类为有潜在消极影响。
8例（16%）阳性结果患者和15例（52%）阴性结果患者的MR波谱分析对治疗有潜在积极影响。2例（3%）患者的MR波谱分析有潜在消极影响。
MR波谱分析在疑似脑肿瘤的管理中可能发挥有益作用。需要进行前瞻性研究以测试MR波谱分析对临床实践的影响，并衡量成本和效益。
