Lebon V, Brillault-Salvat C, Bloch G, Leroy-Willig A, Carlier P G
CEA, Service Hospitalier Frédéric Joliot, Orsay, France.
Magn Reson Med. 1998 Oct;40(4):551-8. doi: 10.1002/mrm.1910400408.
The purpose of this work was to investigate the temporal relationship between intensity changes in T2*-weighted NMR images and tissue oxygen content, measured by myoglobin proton NMR spectroscopy, in the skeletal muscle. During an ischemic stress test, the calf muscles of five healthy volunteers were studied at 3 Tesla. An interleaved NMRI-NMRS sequence was used, which made it possible to record T2*-weighted images and myoglobin spectra simultaneously. During ischemia, rapid changes in muscle signal intensity were observed on T2*-weighted images, which immediately preceded myoglobin desaturation. Bearing in mind the respective P50 of hemoglobin and myoglobin, this observation clearly favored the hypothesis that hemoglobin desaturation was responsible for the changes in T2*. This interpretation was further supported by the temporal coincidence between the experimental NMR data and a model of hemoglobin desaturation solely derived from physiological considerations.
这项工作的目的是研究在骨骼肌中，通过肌红蛋白质子核磁共振波谱法测量的组织氧含量与T2加权核磁共振图像强度变化之间的时间关系。在缺血应激试验期间，对5名健康志愿者的小腿肌肉在3特斯拉磁场下进行了研究。使用了一种交错的核磁共振成像-核磁共振波谱序列，这使得同时记录T2加权图像和肌红蛋白光谱成为可能。在缺血期间，在T2加权图像上观察到肌肉信号强度的快速变化，这紧接在肌红蛋白去饱和之前。考虑到血红蛋白和肌红蛋白各自的P50，这一观察结果明显支持了血红蛋白去饱和是T2变化原因的假说。实验核磁共振数据与仅从生理因素推导出来的血红蛋白去饱和模型之间的时间一致性进一步支持了这一解释。
