Division of Endocrinology and Metabolism, Department of Internal Medicine III & High Field MR Centre, Department of Biomedical Imaging and Image guided Therapy, Medical University of Vienna, Vienna, Austria.
Department of Radiology and Nuclear Medicine and Department of Nutrition and Movement Science, Maastricht University Medical Center, Maastricht, The Netherlands.
NMR Biomed. 2021 May;34(5):e4266. doi: 10.1002/nbm.4266. Epub 2020 Feb 5.
H-MR spectroscopy of skeletal muscle provides insight into metabolism that is not available noninvasively by other methods. The recommendations given in this article are intended to guide those who have basic experience in general MRS to the special application of H-MRS in skeletal muscle. The highly organized structure of skeletal muscle leads to effects that change spectral features far beyond simple peak heights, depending on the type and orientation of the muscle. Specific recommendations are given for the acquisition of three particular metabolites (intramyocellular lipids, carnosine and acetylcarnitine) and for preconditioning of experiments and instructions to study volunteers.
骨骼肌的 H-MR 光谱分析提供了其他非侵入性方法无法获得的代谢见解。本文提出的建议旨在指导那些具有一般 MRS 基本经验的人将 H-MRS 特殊应用于骨骼肌。骨骼肌高度有序的结构会导致光谱特征发生变化，这些变化远不止简单的峰高，具体取决于肌肉的类型和方向。本文还给出了获取三种特殊代谢物（细胞内脂质、肌肽和乙酰肉碱）的具体建议，以及实验预处理和志愿者研究指导。
