Schmeidler J, Mohs R C, Aryan M
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.
Alzheimer Dis Assoc Disord. 1998 Sep;12(3):146-51. doi: 10.1097/00002093-199809000-00005.
Previous studies have shown that the sensitivity of global cognitive and functional measures to change in Alzheimer disease is related to overall disease severity. The present study assessed the sensitivity to decline, over a 12-month interval, for individual items of the cognitive portion of the Alzheimer Disease Assessment Scale (ADAS-Cog), the Instrumental Activities of Daily Living Scale (IADLS), and the Physical Self-Maintenance Scale (PSMS). This study was conducted in an effort to identify individual items likely to be sensitive at different stages of the disease. A total of 151 patients with Alzheimer disease were classified into four dementia categories by baseline scores on the Blessed Test of Information, Memory, and Concentration. The patients were retested after 12 months. For the individual items and for total scores on both the ADAS-Cog and the IADLS, rate of change was greater for patients in the moderate and severe categories than for mild or very severe patients. For individual items and for the total score on the PSMS, rate of change was greater for severe and very severe patients than for patients with mild or moderate disease.
先前的研究表明，全球认知和功能测量对阿尔茨海默病变化的敏感性与疾病的总体严重程度相关。本研究评估了阿尔茨海默病评估量表认知部分（ADAS-Cog）、日常生活能力量表（IADLS）和身体自我维持量表（PSMS）的各个项目在12个月期间对衰退的敏感性。进行这项研究是为了确定在疾病不同阶段可能敏感的各个项目。根据信息、记忆和注意力的Blessed测试的基线分数，将总共151名阿尔茨海默病患者分为四个痴呆类别。12个月后对患者进行重新测试。对于ADAS-Cog和IADLS的各个项目以及总分，中度和重度类别患者的变化率高于轻度或极重度患者。对于PSMS的各个项目和总分，重度和极重度患者的变化率高于轻度或中度疾病患者。
