Li L S, Zheng F, Liu Z H
Research Institute of Nephrology, Jinling Hospital, Nanjing.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996 Dec;16(12):733-7.
In order to evaluate the effect of Cordyceps sinensis (CS) on aminoglycoside (AG) induced nephrotoxicity, gentamycin was imposed on the young and old rats with CS administration. The renal tubular injury was ameliorated as evidenced by less prominent increment of BUN, SCr, sodium excretion, urinary NAGase and less severity of histopathological changes as compared with control. In addition, the use of CS could promote an earlier recovery of renal oxygen consumption insulin clearance, and sodium absorption in isolated perfused kidney from CS treated intoxicated rat than that from control. Possible mechanisms of CS on drug-induced nephrotoxicity include: (1) Accelerating the regeneration of tubular cells; (2) Protecting the sodium pump activity of tubular cells; (3) Attenuating the tubular cell lysosome hyperfunction stimulated by phagocytosis of AG as well as decreasing the tubular cell lipoperoxidation in response to toxic injury; (4) Reducing the tissue Ca++ content.
为了评估冬虫夏草（CS）对氨基糖苷类（AG）诱导的肾毒性的影响，对年轻和老年大鼠施用庆大霉素并同时给予CS。与对照组相比，肾小管损伤得到改善，表现为血尿素氮（BUN）、血清肌酐（SCr）、钠排泄、尿N-乙酰-β-D-氨基葡萄糖苷酶（NAGase）的升高不明显，组织病理学变化的严重程度降低。此外，与对照组相比，使用CS可促进CS处理的中毒大鼠离体灌流肾中肾氧消耗、胰岛素清除率和钠吸收的更早恢复。CS对药物诱导的肾毒性的可能机制包括：（1）加速肾小管细胞的再生；（2）保护肾小管细胞的钠泵活性；（3）减轻AG吞噬刺激的肾小管细胞溶酶体功能亢进，并减少对毒性损伤的肾小管细胞脂质过氧化；（4）降低组织钙含量。
