Tapsall J W, Limnios E A, Shultz T R
Department of Microbiology, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia.
Sex Transm Dis. 1998 Sep;25(8):415-7. doi: 10.1097/00007435-199809000-00005.
Multiple phenotypes of quinolone-resistant Neisseria gonorrhoeae isolated in Sydney since 1984 originated in Asia and increased in number and level of resistance in 1995.
To study the origins, characteristics, and infection pattern of quinolone-resistant Neisseria gonorrhoeae in Sydney from 1995 to 1997 and to compare these results with prior findings.
Quinolone minimal inhibitory concentrations, phenotype, and geographic source of quinolone-resistant Neisseria gonorrhoeae isolated in Sydney from 1995 to 1997 were analyzed.
Two hundred nineteen episodes of infection with quinolone-resistant Neisseria gonorrhoeae from 2,236 gonococcal isolates occurred during 1995 through 1997. The rate of isolation of quinolone-resistant Neisseria gonorrhoeae increased significantly at the end of 1996 and was maintained through 1997. The increase resulted from sustained domestic transmission of a limited number of phenotypes in heterosexual patients.
The pattern of isolation of quinolone-resistant Neisseria gonorrhoeae in Sydney changed from the sporadic isolation of multiple phenotypes of imported quinolone-resistant Neisseria gonorrhoeae to a higher rate of endemic disease caused by a few subtypes. Alterations in antibiotic treatment regimens in the affected patient group were required.
自1984年以来在悉尼分离出的耐喹诺酮淋病奈瑟菌的多种表型起源于亚洲，1995年其数量和耐药水平有所增加。
研究1995年至1997年悉尼耐喹诺酮淋病奈瑟菌的起源、特征和感染模式，并将这些结果与先前的发现进行比较。
分析了1995年至1997年在悉尼分离出的耐喹诺酮淋病奈瑟菌的喹诺酮最低抑菌浓度、表型和地理来源。
1995年至1997年期间，在2236株淋球菌分离物中发生了219例耐喹诺酮淋病奈瑟菌感染。耐喹诺酮淋病奈瑟菌的分离率在1996年底显著增加，并持续到1997年。这种增加是由于有限数量表型在异性恋患者中的持续国内传播所致。
悉尼耐喹诺酮淋病奈瑟菌的分离模式从零星分离多种进口耐喹诺酮淋病奈瑟菌表型转变为少数亚型引起的地方病发病率更高。受影响患者组的抗生素治疗方案需要改变。
