Klisnick A, Schmidt J, Dupond J L, Bouchou K, Rousset H, Thieblot P, Humbert P, Vidal E, Aumaître O
Service de médecine interne, Hôpital Gabriel-Montpied, Clermont-Ferrand, France.
Rev Med Interne. 1998 May;19(5):348-52. doi: 10.1016/s0248-8663(98)80107-0.
The occurrence in the same patient of three or more autoimmune diseases defines multiple autoimmune disease. Multiple autoimmune disease is an unusual condition in which dermatological autoimmune diseases and especially vitiligo have an important place.
We examined retrospectively 11 cases of multiple autoimmune diseases associating vitiligo. We studied the clinical characteristics of vitiligo and those of the associated autoimmune disorders.
Type III multiple autoimmune disease was diagnosed in all the 11 cases observed. Autoimmune vitiligo was the first autoimmune disorder observed in seven cases and was bilateral, symmetrical and acrofacial in eight cases. Autoimmune thyroid disorder was associated in ten cases. Our data confirms the important association between vitiligo and thyroid autoimmune disorders.
The predominant female ratio and the acrofacial topography of skin lesions could predict association with others autoimmune disorders in patients with vitiligo.
同一患者出现三种或更多自身免疫性疾病即定义为多发性自身免疫性疾病。多发性自身免疫性疾病是一种不常见的病症，其中皮肤自身免疫性疾病尤其是白癜风占有重要地位。
我们回顾性研究了11例合并白癜风的多发性自身免疫性疾病病例。我们研究了白癜风的临床特征以及相关自身免疫性疾病的特征。
在所观察的11例病例中均诊断为III型多发性自身免疫性疾病。自身免疫性白癜风是7例中首先观察到的自身免疫性疾病，8例为双侧、对称且肢端颜面型。10例伴有自身免疫性甲状腺疾病。我们的数据证实了白癜风与甲状腺自身免疫性疾病之间的重要关联。
女性占主导比例以及皮肤病变的肢端颜面部位特征可预测白癜风患者与其他自身免疫性疾病的关联。
