烧伤患者血浆中II型磷脂酶A2及亚硝酸盐/硝酸盐的水平

Plasma levels of type II phospholipase A2 and nitrite/nitrate in patients with burns.

作者信息

Yamada Y, Endo S, Kamei Y, Minato T, Yokoyama M, Taniguchi S, Nakae H, Inada K, Ogawa M

机构信息

Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.

出版信息

Burns. 1998 Sep;24(6):513-7. doi: 10.1016/s0305-4179(98)00057-6.

DOI:10.1016/s0305-4179(98)00057-6

PMID:9776089

Abstract

Type II phospholipase A2 (type II PLA2), nitrite/nitrate (NOx), tumor necrosis factor-alpha (TNF-alpha) and endotoxin were studied in burn patients. Type II PLA2 values and NOx values were both significantly higher in the group that died, the group with shock as a complication and the group with multiple organ dysfunction syndrome (MODS) as a complication, than in the group that survived, the group without shock as a complication and the group without MODS as a complication, respectively. The results suggested that type II PLA2 and nitric oxide (NO) may play a major role in the pathology of burn patients. Significant correlations were found between TNF-alpha and type II PLA2 values and between type II PLA2 and NOx values, suggesting the possibility of involvement in each other's production.

摘要

对烧伤患者的II型磷脂酶A2（II型PLA2）、亚硝酸盐/硝酸盐（NOx）、肿瘤坏死因子-α（TNF-α）和内毒素进行了研究。II型PLA2值和NOx值在死亡组、并发休克组和并发多器官功能障碍综合征（MODS）组中均分别显著高于存活组、无休克并发症组和无MODS并发症组。结果表明，II型PLA2和一氧化氮（NO）可能在烧伤患者的病理过程中起主要作用。发现TNF-α与II型PLA2值之间以及II型PLA2与NOx值之间存在显著相关性，提示它们可能参与彼此的产生过程。