Takakuwa T, Endo S, Inada K, Kasai T, Yamada Y, Ogawa M
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Res Commun Mol Pathol Pharmacol. 1997 Oct;98(1):43-52.
Plasma endotoxin levels, nitrate/nitrite (NOx), type II phospholipase A2 (PLA2), soluble adhesion molecules, and inflammatory cytokines were measured in 34 patients with systemic inflammatory response syndrome (SIRS). Significant correlations were found between NOx values, PLA2 values, soluble adhesion molecules, and inflammatory cytokines, suggesting the possibility that these factors were deeply affected each other. When the 34 SIRS patients were divided into the group with sepsis (n = 20) and with the group with trauma without documented infection (n = 14), despite the fact that the difference in APACHE II scores was not significant, all of the factors except endotoxin were significantly higher in the sepsis group than in the trauma group, and the outcome was death in 4 of the 14 patients in the trauma group (28.6%), as opposed to 14 of the 20 patients in the sepsis group (70.0%). The mediator values measured in this study seemed to reflect the difference in the severity of the patients' disease and their outcome.
对34例全身炎症反应综合征（SIRS）患者测定了血浆内毒素水平、硝酸盐/亚硝酸盐（NOx）、II型磷脂酶A2（PLA2）、可溶性黏附分子和炎性细胞因子。发现NOx值、PLA2值、可溶性黏附分子和炎性细胞因子之间存在显著相关性，提示这些因素可能相互之间受到深刻影响。当将34例SIRS患者分为脓毒症组（n = 20）和无感染记录的创伤组（n = 14）时，尽管急性生理学及慢性健康状况评分系统II（APACHE II）评分差异不显著，但除内毒素外，脓毒症组所有因素均显著高于创伤组，创伤组14例患者中有4例死亡（28.6%），而脓毒症组20例患者中有14例死亡（70.0%）。本研究中测定的介质值似乎反映了患者疾病严重程度及其预后的差异。
