Parker A C, Bain A D, Brydon W G, Harkness R A, Smith A F, Smith I I, Boyd D H
J Clin Pathol. 1976 Jul;29(7):634-8. doi: 10.1136/jcp.29.7.634.
A patient with sea-blue histiocytosis in spleen and bone marrow with an accompanying hyperlipidaemia is described. The hyperlipidaemia was due to an increase in "free" cholesterol, lecithin, and triglycerides. Despite these findings lecithin-cholesterol acyl transferase activity was normal. Although the precise biochemical defect was not identified, there was a failure of transport of cholesterol from chylomicrons in vitro. We propose that the sea-blue histiocyte is a marker, in some cases, of abnormal lipid metabolism.
本文描述了一名脾脏和骨髓中存在海蓝色组织细胞增多症并伴有高脂血症的患者。高脂血症是由于“游离”胆固醇、卵磷脂和甘油三酯增加所致。尽管有这些发现，但卵磷脂胆固醇酰基转移酶活性正常。虽然未确定确切的生化缺陷，但在体外乳糜微粒中的胆固醇转运存在障碍。我们提出，在某些情况下，海蓝色组织细胞是脂质代谢异常的一个标志物。
