Kelly K M
Center for Neurosciences Research, Allegheny University of the Health Sciences Pittsburgh, PA 15212-4772, USA.
Neuropsychobiology. 1998 Oct;38(3):139-44. doi: 10.1159/000026529.
Gabapentin is an antiepileptic drug used in the treatment of partial and generalized tonic-clonic seizures. Its antiepileptic mechanism of action is not known. The transport of gabapentin across membranes and its demonstrated effects on voltage-gated ion channels (sodium, calcium), presynaptic mechanisms that can enhance GABAergic inhibition, and ligand-gated ion channels (GABA receptors and glutamate receptors) are reviewed.
加巴喷丁是一种用于治疗部分性发作和全身性强直阵挛性发作的抗癫痫药物。其抗癫痫作用机制尚不清楚。本文综述了加巴喷丁跨膜转运情况及其对电压门控离子通道（钠通道、钙通道）、可增强γ-氨基丁酸（GABA）能抑制作用的突触前机制以及配体门控离子通道（GABA受体和谷氨酸受体）的已证实作用。
