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伯基特淋巴瘤的免疫组织化学特征

Immunohistochemical characterization of Burkitt's lymphoma.

作者信息

Kaschula R O, Staples W G, Visser A E

出版信息

S Afr Med J. 1978 Apr 29;53(17):655-8.

PMID:97795
Abstract

Cytoplasmic immunoglobulins and muramidase (lysozyme) were demonstrated in formalin-fixed tissues by an immunoperoxidase procedure in 3 cases of Burkitt's lymphoma. The Burkitt cells were strongly positive with the full panel of monospecific antisera against human immunoglobulin components (kappa and lambda light chains, gamma, alpha and micron heavy chains). The 'starry-sky' macrophages were weakly positive with antimuramidase antiserum and strongly positive with the antisera against immunoglobulins, thus demonstrating their phagocytic and histiocytic nature. The reasons for the polyclonal increase in immunoglobulins are discussed.

摘要

通过免疫过氧化物酶法在3例伯基特淋巴瘤的福尔马林固定组织中检测到细胞质免疫球蛋白和溶菌酶。伯基特细胞对全套抗人免疫球蛋白成分(κ和λ轻链、γ、α和μ重链)的单特异性抗血清呈强阳性。“星空”巨噬细胞对抗溶菌酶抗血清呈弱阳性,而对抗免疫球蛋白抗血清呈强阳性,从而证实了它们的吞噬和组织细胞性质。文中讨论了免疫球蛋白多克隆增加的原因。

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