2-脱氧-2,3-脱氢-N-三氟乙酰神经氨酸（FANA）对组织培养中流感病毒复制的抑制作用：作用机制
Inhibition of influenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA): mechanism of action.
作者信息
Palese P, Compans R W
出版信息
J Gen Virol. 1976 Oct;33(1):159-63. doi: 10.1099/0022-1317-33-1-159.
PMID:978183
Abstract
The neuraminidase inhibitor 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA) inhibits the mutlicycle replication of influenza viruses in tissue culture. Influenza virus grown in the presence of FANA contains neuraminic acid on its envelope which then serves as receptor for other virus particles causing extensive aggregation. Thus, FANA inhibits influenza virus replication by preventing the enzymatic removal of neuraminic acid from the virus envelope.
摘要
神经氨酸酶抑制剂2-脱氧-2,3-脱氢-N-三氟乙酰神经氨酸（FANA）可抑制流感病毒在组织培养中的多循环复制。在FANA存在的情况下生长的流感病毒在其包膜上含有神经氨酸，该神经氨酸随后作为其他病毒颗粒的受体，导致广泛聚集。因此，FANA通过阻止从病毒包膜上酶促去除神经氨酸来抑制流感病毒复制。
Zotero 插件