Hayashi H, Hiraoka N, Ikeshiro Y, Yamamoto H, Yoshikawa T
Niigata College of Pharmacy, Japan.
Biol Pharm Bull. 1998 Sep;21(9):987-9. doi: 10.1248/bpb.21.987.
The time courses of the glycyrrhizin and isoliquiritigenin glycoside contents in the thickening roots of licorice, Glycyrrhiza glabra L., have been determined. The glycyrrhizin content in 1-year-old roots rapidly increased from October to November, whereas the isoliquiritigenin glycoside content increased up to October. In 3-year-old plants, although the isoliquiritigenin glycoside content rapidly increased from June to July, the glycyrrhizin content did not show any significant increase from May to August. The glycyrrhizin content increased during the senescence of the aerial parts as well as during the early stage of shoot elongation. The incorporation of [14C]mevalonic acid into the glycyrrhizin fraction by the root segments was high in May, June and September, and low in August and winter. These results indicated that the biosynthesis of glycyrrhizin is differently regulated from that of isoliquiritigenin glycoside in the thickening root of G. glabra.
已测定光果甘草（Glycyrrhiza glabra L.）加粗根中甘草酸和异甘草素糖苷含量的时间进程。1年生根中甘草酸含量在10月至11月迅速增加，而异甘草素糖苷含量在10月前增加。在3年生植株中，虽然异甘草素糖苷含量在6月至7月迅速增加，但甘草酸含量在5月至8月没有显著增加。地上部分衰老期间以及枝条伸长早期甘草酸含量增加。5月、6月和9月根段将[14C]甲羟戊酸掺入甘草酸部分的量较高，8月和冬季较低。这些结果表明，光果甘草加粗根中甘草酸的生物合成与异甘草素糖苷的生物合成受到不同的调控。
