茯苓酸酯对发芽、α-淀粉酶和羧肽酶A的抑制活性研究。

Studies on inhibitory activities of fukiic acid esters on germination, alpha-amylase and carboxypeptidase A.

作者信息

Kusano G, Takahira M, Shibano M, Kusano A, Okamoto Y, Tsujibo H, Numata A, Inamori Y

机构信息

Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.

出版信息

Biol Pharm Bull. 1998 Sep;21(9):997-9. doi: 10.1248/bpb.21.997.

DOI:10.1248/bpb.21.997

PMID:9781856

Abstract

Fukinolic acid (1) and cimicifugic acid A (2), caffeic acid analogs, as well as rosmarinic acid (3) and caffeic acid (4) showed inhibition on seed germination and seedling growth. The potency of 1 and 2 was comparable with that of 3. Compounds 1 and 2 also showed strong inhibitory activities as well as 3 and 4 on alpha-amylase. The activity of 1 was higher than that of acarbose used as a positive control, and its 50% inhibitory concentration (IC50) was 2.41 x 10(-5) M. Compounds 1 and 2 also showed inhibitory activities strong as 3 and stronger than 4 on carboxypeptidase A. The activities of 1 and 2 were higher than that of 1, 10-phenanthroline used as a positive control.

摘要

升麻醇木糖苷（1）和升麻酸A（2），即咖啡酸类似物，以及迷迭香酸（3）和咖啡酸（4）均对种子萌发和幼苗生长有抑制作用。1和2的效力与3相当。化合物1和2以及3和4对α-淀粉酶也表现出较强的抑制活性。1的活性高于用作阳性对照的阿卡波糖，其50%抑制浓度（IC50）为2.41×10⁻⁵ M。化合物1和2对羧肽酶A也表现出与3相当且强于4的抑制活性。1和2的活性高于用作阳性对照的1,10-菲啰啉。