来自总状升麻根茎的升麻酸酯和鱼藤酸酯以及升麻醇酸的体外雌激素活性。

Fukiic and piscidic acid esters from the rhizome of Cimicifuga racemosa and the in vitro estrogenic activity of fukinolic acid.

作者信息

Kruse S O, Löhning A, Pauli G F, Winterhoff H, Nahrstedt A

出版信息

Planta Med. 1999 Dec;65(8):763-4. doi: 10.1055/s-2006-960862.

DOI:10.1055/s-2006-960862

Abstract

Hydroxycinnamic acid esters of fukiic acid and piscidic acid were isolated from a 50% ethanolic extract obtained from the rhizomes of Cimicifuga racemosa (Ranunculaceae). Besides 2-E-caffeoylfukiic acid (fukinolic acid), 2-E-feruloylfukiic acid (cimicifugic acid A), 2-E-isoferuloylfukiic acid (cimicifugic acid B), 2-E-feruloylpiscidic acid (cimicifugic acid E) and 2-E-isoferuloylpiscidic acid (cimicifugic acid F), free caffeic, ferulic and isoferulic acids were isolated. The estrogenic activity of fukinolic acid was shown by increased proliferation (126% at 5 x 10(-8) M) of an estrogen dependent MCF-7 cell system with reference to estradiol (120% at 10(-10) M).

摘要

从毛茛科植物总状升麻根茎的50%乙醇提取物中分离得到了升麻酸和鱼石酸的羟基肉桂酸酯。除了2-E-咖啡酰升麻酸（升麻醇酸）、2-E-阿魏酰升麻酸（升麻酸A）、2-E-异阿魏酰升麻酸（升麻酸B）、2-E-阿魏酰鱼石酸（升麻酸E）和2-E-异阿魏酰鱼石酸（升麻酸F）外，还分离得到了游离的咖啡酸、阿魏酸和异阿魏酸。与雌二醇（10(-10) M时为120%）相比，升麻醇酸使雌激素依赖性MCF-7细胞系统的增殖增加（5×10(-8) M时为126%），从而显示出其雌激素活性。